Serum and urine are the primary diagnostic specimens for Zika virus infection. Molecular testing of Zika virus RNA in serum and in urine collected from symptomatic individuals can be an effective aid to diagnose a recent Zika virus infection. If Zika rRT-PCR testing was conducted for a patient and any of the patient’s specimens yielded positive results, the patient is positive for Zika infection. No antibody testing is required. If molecular test is negative for Zika virus, antibody detection should be performed on serum specimen. If any IgM assay yields positive or equivocal results for a specimen, results must be confirmed. See the complete guidelines here.